Nicotinamide Adenine Dinucleotide — a coenzyme found in every living cell. Central to how your body produces energy, repairs DNA, and activates the sirtuin enzymes linked to longevity. NAD+ levels decline by roughly 50% between your 20s and 60s — and this decline is now considered a key mechanism in cellular aging.
Also known as: Nicotinamide Adenine Dinucleotide, Beta-NAD+, Coenzyme I, DPN
NAD+ is not a supplement — it is a fundamental cellular molecule your body has always made. The problem is that production slows significantly with age, and the consequences ripple across every system that depends on it: energy production, DNA repair, immune function, and metabolism.
Approximate NAD+ plasma levels across age groups — Cell Metabolism, Gomes et al., 2013
Cell Metabolism, 2013 ›NAD+ operates simultaneously as an energy carrier and a signaling molecule. Its dual role means that when levels fall, it affects both how much energy your cells produce and how well they protect and repair themselves.
| Finding | Study Type | Observed Effect | Source |
|---|---|---|---|
| NAD+ Decline | Human and animal | ~50% by age 60 | Cell Metabolism, 2013 |
| Sirtuin Activity | Aged vs restored | 85% improvement | Multiple studies |
| Muscle Function | Aged mice + NMN | Significant improvement | Cell Metabolism, 2013 |
| Mitochondrial Function | Aged tissue | Restored toward young | Nature Comms, 2016 |
| Human NAD+ Levels | Precursor supplementation | Significant increase | Cell Metabolism, 2016 |
NAD+ is a naturally occurring cellular molecule present in every living cell. It has an exceptionally well-established safety profile across decades of research and clinical use.
As a naturally occurring cellular molecule, NAD+ has an intrinsically favourable safety profile. Most reported side effects in studies have been mild and transient — primarily mild flushing at high doses. No serious adverse events have been reported in any published NAD+ study.
Research Use Only. Human clinical data is primarily from studies using NAD+ precursors (NMN, NR). Sold for research purposes only. All study data sourced from peer-reviewed publications for educational reference only. By purchasing you confirm you are a qualified researcher. View full policy.